• Жидкие лекарственные формы
    • Dara
      Комплексные линии розлива и укупорки для флаконов, картриджей и шприцев
    • Ellab
      Решения для валидации и мониторинга процессов
    • Extract Technology
      Герметичные и асептические системы для фармацевтических, медицинских, биотехнологических и химических рынков
    • Fedegari Autoclavi SPA
      Автоклавы, изоляторы, сухожаровые шкафы и депирогенизаторы
    • GEA Lyophil
      Лиофильные сушки и системы выгрузки/загрузки флаконов на полки
    • GEA Niro Soavi
      Сепараторы и гомогенизаторы высокогого давления
    • Optrel
      Автоматические инспекционные машины для проверки заполненных фармацевтических контейнеров для жидких и лиофилизированных продуктов
  • Чистые среды
    • Tecninox
      Оборудование для производства инъекционных и инфузионных растворов, ферментации, сепарации плазмы, водоподготовка
  • Твердые лекарственные формы
    • Frewitt
      Молотковые, конические и осцилляционные мельницы
    • GEA Aeromatic-Fielder™
      Высокоскоростные миксеры и процессоры в псевдоожиженном слое
    • GEA Buck® & Buck Systems™
      Герметичные соединительные системы для перегрузки продуктов
    • GEA Collette™
      Миксеры-грануляторы с верхним приводом, однокамерные процессоры, непрерывные системы грануляции
    • GEA Courtoy™
      Высокоскоростные роторные таблетпрессы
    • kg-pharma
      Tablet presses
    • NOTTER
      Таблеточный пресс-инструмент премиум класса
    • Pharma Technology S.A.
      Обеспыливатели для таблеток и капсул, таблеттестеры
    • ProCepT
      Компания ProCepT является производителем технологического оборудования и поставщиком услуг для процессов сушки, агломерации, покрытия и смешивания
    • Xedev
      Xedev является поставщиком услуг в области инжиниринга частиц и разработки процессов

Blood Plasma

Complete solutions

The fractionation process is based on the different solubility of the plasma proteins in relation to different conditions of some parameters, bath chemical end physical, like ethanol concentration, temperature, pH, ionie strenght. To get homogeneily in batches of plasma from thousands of donations and reduce the risk of virai transmission, before the definitive release for pockoging, plasma products always undergo several virus inactivation steps depending on the final product, such as:
· Postorizotion
· Heating of freeze dried products
· Detergenti solvent treatment
· Nanofiltration
· Low pH
· Chromotography
· Sterile filtration

Afterwards many different separation steps could follow one another:
· Cryo-precipitation
· lon exchange chromatography
· Affinity chromatography
· Alcohol precipitation
· precipitation
· PEG precipitation
· Centrifugation
· Ultrafiltration
· Partitioning through filter press

Human Plasma is not only a /ife element of our body;
its the key element in immunedeficienciesand other diseases treatments.

The large part of plasma-derived products can only be treated from plasma,and plasma can only be extracted from human donors. Consequently, plasma is a finite resource that cannot be replicated or mass produced in large industriai process.
TECNinox has realized many plants for leading companies in plasma fractionation. Today, modern fractionation plants are large and complex. capable of fractionating millions of litres of plasma into a variety of therapeutic products. lhus, the plasma must be used efficiently by producing as many products as possible from each liter collected. lhe conditions under which take piace all plasma fractionation steps are very important;for example the temperature of buffer addition in precipitation tanks, the pH of suspension before each filtration or centrifugation, the optical density of permeate during the Albumin Ultrafiltration.

Furthennore, efficiency is also achieved by TECNinox system improving the most advanced manufacturing concepts for vessels and valve technology. The piping shall strictly comply with the capacity and heating and cooling system parameters, and the proper CIP/ SIP engineering has to be up to an organic materiai treatment plant in which the bacteria can grow very quickly.

Different plasma-derived products can be obtained from plasma fractionation

The whole Plasma Fractionation Plant that TECNinox can provide is the result of an engineered study based on a deep knowledge of the productive process acquired over the years working in close contact with customer, talking to production operators, understanding their needs and always sharing advanta-ges and potential problems.

An automatic or semi-automatic control system supervises each process recipe or maintenance phase; the system allows the customer to monitor and record all process parameter, both critical and not critical, it can guide the operator in each process operation and became a batch record visualised on the Operator Panel: user friendly and mistake proof are our key words.

Our strength is the competence and reliability largely feel by anyone who entrusts to us, right from the stage of basic design and process engineering.